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Cao, Q., Mak, K. M., and Lieber, C. S. (2006). Online Mendelian Inheritance in Man (OMIM®), an Online Catalog of Human Genes and Genetic Disorders. In general Chuan Xiong's main actions are as follows: "Regulates and moves the Blood.
HSC hepatic stellate cells. The CCl4 (C112045) and olive oil (O108686) were purchased from Shanghai Aladdin Biochemical Technology Co., LTD (Shanghai, China). In conclusion, through the combination of network pharmacology and experimental verification, this study offered more insight molecular mechanisms of GXZY on LC. A single formula, alone, may not be sufficient to fully address a particular TCM diagnostic pattern. Multi-Component Comparative Pharmacokinetics in Rats after Oral Administration of Fructus Aurantii Extract, Naringin, Neohesperidin, and Naringin-Neohesperidin. Inhibition of TNF pathway can reduce inflammatory stimulation and inhibit the formation of liver fibrosis. Zhang, W., Huai, Y., Miao, Z., Qian, A., and Wang, Y. 2 Institute of Liver Diseases, Beijing University of Chinese Medicine, Beijing, China. Hui, T., Bai, G., and Liu, F. What is ge xia zhu yu tang used for. (2016). Disclaimer: These statements have not been evaluated by the FDA. Moreover, in the present study, GXZY is also used in treating clinical chronic liver diseases such as liver fibrosis and cirrhosis, and it is reported that GXZY exhibited an excellent anti-liver fibrosis effect in treating chronic hepatitis B (CHB) (Hui, 2016) (Ma, 2015).
This study aimed to explore the therapeutic mechanisms of traditional Chinese medicine GXZY on LC by using the comprehensive research method based on network pharmacology. Qing-ren's Qing dynasty Yi Lin Gai Cuo (Correcting the Errors in the Forest of. Ge Xia Zhu Yu Tang › Veterinarian Recommended Holistic Pet Products. Irregular menstruation, amenorrhea, excessive uterine bleeding or spotting between cycles. Tumor Necrosis Factor-like Weak Inducer of Apoptosis Promotes Hepatic Stellate Cells Migration via Canonical NF-Κb/mmp9 Pathway.
GXZY might affect the MAPK signaling pathway, TNF signaling pathway, hepatitis B, and pathways in cancer and prevent the progress of liver fibrosis and the occurrence of liver cancer. Share your opinion with other customers Leave my review. Breast distention distention and pain. Tao Ren, Hong Hua and Wu Ling Zhi: Breaking blood and eliminating stasis. And the key targets were significantly related to multiple GO-BP, including response to drug, negative regulation of apoptotic process, and positive regulation of transcription, DNA-templated (Figure 3B). Ge xia zhu yu tang side effects. Phlebitis, generally chronic. We use the Analyzer plugin to analyze the PPI network and get the degree, through taking over a double median of degree to get the preliminary hub network (Zhang et al., 2014). Invigorate blood, alleviate pain - pain from blood stasis and trauma, dysmenorrhea. Bioinformatics 54, 1. Collection of Chemical Compounds in GXZY.
The qRT-PCR was performed using the Real-time PCR Detection System (Agilent Technologies, US) with the SYBR Green Real-time PCR Master Mix (TOYOBO, JAN). We demonstrate that the pharmacological effects of GXZY is mainly through reducing liver injury, inhibiting inflammatory response, reducing intrahepatic collagen deposition, and inhibiting the proliferation and migration of HSC. For a range of stagnation issues in the stomach/epigastric/heart region - gastritis, epigastric pain, peptic ulcer disease. Piñero, J., Ramírez-Anguita, J. M., Saüch-Pitarch, J., Ronzano, F., Centeno, E., Sanz, F., et al. These results further supported the pharmacological effects of GXZY on LC via inhibiting the proliferation and migration of HSC and down-regulating the expression of key gene MMP9. Dennis, G., Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., Lane, H. C., et al. The GO and KEGG functional enrichment of key target genes. Returns Accepted Safe and secure payments. Hoehes33342 counterstained the nucleus, and the fluorescence was blue. Uncovering the Pharmacological Mechanisms of Gexia-Zhuyu Formula (GXZY) in Treating Liver Cirrhosis by an Integrative Pharmacology Strategy. A range of liver issues including hepatitis and cirrhosis. In general Zhi Ke's main actions are as follows: "To regulate the flow of Qi, remove its stagnation, and alleviate distension.
VETERINARY AUTHORIZATION IS REQUIRED. The economic sanctions and trade restrictions that apply to your use of the Services are subject to change, so members should check sanctions resources regularly. At the end of the 12th week, ALT, AST, and ALP levels decreased in GXZT group compared with the model group (Figure 4D). All formulas in the primary category of "invigorate the blood" are listed below. Stasis include: Fixed, severe, and/or. Ge xia zhu yu tanguy. The primary antibody of Western Blotting experiment is anti-MMP9 (ab76003, Abcam, UK) and internal reference antibody is Beta Actin Monoclonal antibody (66009-1, Proteintech, United States).
Treatment Principles. Materials and Methods.